Scientific base
Chlorine dioxide
The core of BlockerVirus is the active substance chlorine dioxide (ClO2). The chemical compound has been used for more than 70 years as a strong and effective remedy for deodorization and disinfection, has a strong bactericidal (kills dangerous microorganisms), virucidal (kills microbes that can cause disease), fungicidal (reduces fungal formations and their derivatives, etc.) and other effects. Chlorine dioxide is able to quickly destroy viral infections that are airborne transmitted. It inactivates spores, fungal moulds, bacteria and other very dangerous agents that are in the air, water, on surfaces. When dangerous microorganisms penetrate the cell structure, chlorine dioxide enters into a destructive reaction and disrupts their functioning systems. There are no protective mechanisms against the effects of chlorine dioxide in pathogens, and therefore chlorine dioxide provides a wide range of protection.

Chlorine dioxide has a strong oxidizing potential, many times higher than that of other disinfectants, due to this there is maximum exposure and destruction of pathogenic infecting agents in humans and animals.

Chlorine dioxide purifies the air from odor nuisance, acts on its sources, and has a very high penetration capacity. After activation of the BlockerVirus, the air is clean and filled with freshness.

Chlorine dioxide is widely used all over the world, for example, in agriculture, cosmetics, food raw material preparation, water purification and many other areas.

The pioneer and creator of the virus blockers was Japan. More than 10 years ago the first blocker-badge of individual wearing was created to protect against viruses. In this short time, this product has proven to be an effective tool and enjoys wide popularity. A lot of research on this topic has been conducted, all tests have shown the reliability of blockers protection from pathogens.

Six-month low level chlorine dioxide gas inhalation toxicity study with two-week recovery period in rats.

BACKGROUND: Chlorine dioxide (CD) gas has a potent antimicrobial activity at extremely low concentration and may serve as a new tool for infection control occupationally as well as publicly. However, it remains unknown whether the chronic exposure of CD gas concentration effective against microbes is safe. Therefore, long-term, low concentration CD gas inhalation toxicity was studied in rats as a six-month continuous whole-body exposure followed by a two-week recovery period, so as to prove that the CD gas exposed up to 0.1 ppm (volume ratio) is judged as safe on the basis of a battery of toxicological examinations.

METHODS: CD gas at 0.05 ppm or 0.1 ppm for 24 hours/day and 7 days/week was exposed to rats for 6 months under an unrestrained condition with free access to chow and water in a chamber so as to simulate the ordinary lifestyle in human. The control animals were exposed to air only. During the study period, the body weight as well as the food and water consumptions were recorded. After the 6-month exposure and the 2-week recovery period, animals were sacrificed and a battery of toxicological examinations, including biochemistry, hematology, necropsy, organ weights and histopathology, were performed.

RESULTS: Well regulated levels of CD gas were exposed throughout the chamber over the entire study period. No CD gas-related toxicity sign was observed during the whole study period. No significant difference was observed in body weight gain, food and water consumptions, and relative organ weight. In biochemistry and hematology examinations, changes did not appear to be related to CD gas toxicity. In necropsy and histopathology, no CD gas-related toxicity was observed even in expected target respiratory organs.

CONCLUSIONS: CD gas up to 0.1 ppm, exceeding the level effective against microbes, exposed to whole body in rats continuously for six months was not toxic, under a condition simulating the conventional lifestyle in human.

Primary source: (English)
Ten-week Whole-body Inhalation Toxicity Study of Chlorine Dioxide Gas in Rats
Abstract: Chlorine dioxide (ClO2 ) gas can protect against influenza virus infection at a concentration of 0.03 parts par million (volume/volume), which is believed to be nontoxic in humans. This suggests an opportunity for the development of a novel protective method against airborne infectious diseases. This method is especially applicable to the highly pathogenic H5N1 influenza virus, as there is currently no safe and effective protection against H5N1. However, concerns remain regarding the safety of ClO2 gas for protection against virus infection, especially whether a concentration of 0.03 parts per million is really non-toxic when it is used for humans in closed or semiclosed spaces. In view of the importance of the usefulness and necessity of low concentration ClO2 gas treatment, it is critical to determine the "no observed adverse effect level" (NOAEL) of ClO2 gas. In 1972 Paulet and Desbrousses reported that the "lowest observed adverse effect level" (LOAEL) of ClO2 gas was 1 part per million. We attempted to confirm their data under carefully designed experimental conditions. Here, we performed a rat hole-body inhalation toxicity study, where rats were exposed to 1 part per million ClO2 gas for 5 hours per day and 5 days per week over a period of 10 weeks. The rats were exposed to a meticulously controlled low-concentration ClO2 gas. No adverse effect was observed under these experimental conditions in contrast to the study by Paulet and Desbrousses. We conclude that the no observed adverse effect level of ClO2 gas at these experimental conditions is 1 ppm. We hope this result will help develop a preventive method against airborne microbial infectious diseases of humans.

Primary source: (English)
Protective effect of low-concentration chlorine dioxide gas against influenza A virus infection.

Abstract: Influenza virus infection is one of the major causes of human morbidity and mortality. Between humans, this virus spreads mostly via aerosols excreted from the respiratory system. Current means of prevention of influenza virus infection are not entirely satisfactory because of their limited efficacy. Safe and effective preventive measures against pandemic influenza are greatly needed. We demonstrate that infection of mice induced by aerosols of influenza A virus was prevented by chlorine dioxide (ClO(2)) gas at an extremely low concentration (below the long-term permissible exposure level to humans, namely 0.1 p.p.m.). Mice in semi-closed cages were exposed to aerosols of influenza A virus (1 LD(50)) and ClO(2) gas (0.03 p.p.m.) simultaneously for 15 min. Three days after exposure, pulmonary virus titre (TCID(50)) was 10(2.6+/-1.5) in five mice treated with ClO(2), whilst it was 10(6.7+/-0.2) in five mice that had not been treated (P=0.003). Cumulative mortality after 16 days was 0/10 mice treated with ClO(2) and 7/10 mice that had not been treated (P=0.002). In in vitro experiments, ClO(2) denatured viral envelope proteins (haemagglutinin and neuraminidase) that are indispensable for infectivity of the virus, and abolished infectivity. Taken together, we conclude that ClO(2) gas is effective at preventing aerosol-induced influenza virus infection in mice by denaturing viral envelope proteins at a concentration well below the permissible exposure level to humans. ClO(2) gas could therefore be useful as a preventive means against influenza in places of human activity without necessitating evacuation.

Primary source: (English)
Study of efficiency of the new type of air disinfector — chlorine dioxide generator by the example of A (H1N1)pdm09 influenza as a aerosol component.

Approaches to prevention of respiratory viral infections were considered, including application of inactivation drugs for extracellular virus on the surfaces and inside the facilities, which allows to prevent contamination in gathering of people.

Primary source: (Russian)
Inactivation of Airborne Bacteria and Viruses Using Extremely Low Concentrations of Chlorine Dioxide Gas.


Infectious airborne microbes, including many pathological microbes that cause respiratory infections, are commonly found in medical facilities and constitute a serious threat to human health. Thus, an effective method for reducing the number of microbes floating in the air will aid in the minimization of the incidence of respiratory infectious diseases. Here, we demonstrate that chlorine dioxide (ClO2) gas at extremely low concentrations, which has no detrimental effects on human health, elicits a strong effect to inactivate bacteria and viruses and significantly reduces the number of viable airborne microbes in a hospital operating room. In one set of experiments, a suspension of Staphylococcus aureus, bacteriophage MS2, and bacteriophage ΦX174 were released into an exposure chamber. When ClO2 gas at 0.01 or 0.02 parts per million (ppm, volume/volume) was present in the chamber, the numbers of surviving microbes in the air were markedly reduced after 120 min. The reductions were markedly greater than the natural reductions of the microbes in the chamber. In another experiment, the numbers of viable airborne bacteria in the operating room of a hospital collected over a 24-hour period in the presence or absence of 0.03 ppm ClO2 gas were found to be 10.9 ± 6.7 and 66.8 ± 31.2 colony-forming units/m3 (n = 9, p < 0.001), respectively. Taken together, we conclude that ClO2 gas at extremely low concentrations (≤0.03 ppm) can reduce the number of viable microbes floating in the air in a room. These results strongly support the potential use of ClO2 gas at a non-toxic level to reduce infections caused by the inhalation of pathogenic microbes in nursing homes and medical facilities.

Primary source: (English)
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